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Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
The microbial rhodopsin protein, Archaerhodopsin 3, can function as a rapid and highly sensitive genetically encoded voltage indicator in mammalian cells that is capable of detecting single action potentials with a signal-to-noise ratio greater than 10. A mutant lacking proton pumping displays greater sensitivity but a slowed response.
- Joel M Kralj
- , Adam D Douglass
- & Adam E Cohen
