Featured
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News & Views |
Stress fibres and the cortex work in tandem
Stress fibres form a fully integrated meshwork with the submembranous contractile actin cortex that generates and propagates traction forces across the entire cell.
- Guillaume Charras
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Article |
Stress fibres are embedded in a contractile cortical network
The mechanism of stress fibre assembly by the coalescence of actin filaments in the cell cortex has now been found to account for the transmission of mechanical forces throughout the entire cell along stress fibres.
- Timothée Vignaud
- , Calina Copos
- & Laetitia Kurzawa
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News & Views |
Life and death agendas of actin filaments
Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
- Edna C. Hardeman
- & Peter W. Gunning
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News & Views |
Bundles from boundaries
Using a micropatterning technique, the architecture of actin networks is revealed to be influenced by the spatial organization of actin filament nucleation. Considering the geometric boundaries within live cells, implications in the realm of actin-induced cell functions are vast.
- Denis Wirtz
- & Shyam B. Khatau
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Letter |
Nucleation geometry governs ordered actin networks structures
Actin filaments are a principal component of the cell cytoskeleton. Using micropatterning methods, physical influences on the growth of highly ordered actin structures are investigated. The spatial organization of actin nucleation sites is discovered to play an important role in establishing the architecture of actin networks.
- Anne-Cécile Reymann
- , Jean-Louis Martiel
- & Manuel Théry
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation