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Not clear about how meiosis works. How do homologous chromosomes cross over one another before the fusion of gametes?
Asked by: Disha K
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What does reproducibility & dominant inheritance mean?
(These are said to be majoe limitations of RAPD)
Asked by: Sunanda Nath
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What do you think about the following query about a couple of a 32 year-old Asian woman a 30 year-old white man. If they have kids within the next 2 years, what is the chance (%) will the man's mental disorders passed down to their mixed offsprings given the following details:
The man was diagnosed with ADD since a kid and showed anxiety symptoms since high school: getting anxious in class when having a wrong answer, not showing up for school which affect his school performance. Now he seems to show little sign of anxiety, said he enjoys his job and said it helps him with his anxiety.
In his family, a maternal grandmother turned 'braindead' (his word) when she turned 70. Both of his parents are anesthesiologist and seem intelligent mentally sane. He said his dad is very introverted, and his mom's brother is (medically) insane.
Asked by: M N
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Hi,
Other than the multiple following issues, the patient is a usually healthy, robust 42yo male.
Patient was born with an undescended right testicle, but has normal male genitalia.
The patient and his wife (who has been able to bear 2 children in a previous marriage) have been trying unsuccessfully to get pregnant for the past 4 years.
A genetic test which found “46, XX”, also indicated a pericentric inversion in chromosome 2 [“inv(2)(p11.2q13)”], and also confirmed CLL [due to “del(13)(q12q22)”] :
“Results
46,XX,inv(2)(p11.2q13)?c, del(13)(q12q22)[2]/
46,XX,inv(2)(p11.2q13)?c[16]
Interpretation:
Abnormal female karyotype at the 350 band level as determined by the trypsin-Giemsa method.
Analysis showed a deletion the long arm of chromosome 13 in 2 cells (11%).
In addition, an inversion of chromosome 2 was observed in all cells.”
My questions are:
1. What is the clinical meaning of “46,XX”?
2. What is the clinical meaning of “Abnormal female karyotype”?
3. Is the patient genetically a female?
4. Is the patient irreversibly infertile?
5. Does the inversion in chromosome 2 [inv(2)(p11.2q13)] contribute to infertility?
Thanks!
Asked by: David Hockney
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Ok..i understand that monosomy x is current state of human males... But my point of view is that if SRY will switch to another chromosome i.e to an autosome then they'll become a 45 chromosome human male... Why is that you don't consider it abnormal? Like a world with females having 46 chromosomes and males having 45 chromosomes.
And secondly, y chromosome is shrinking due to inversions which prevented full recombination between x and y chromosomes. So why inversions occur? Like why?
Asked by: Moatter G
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Scitable the World's Best Genetics Study Group
Disha K
  • Location: India

  • I Am A: High School Student

Sunanda Nath
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  • I Am A: Graduate Student


M N
  • Location: United States

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David Hockney
  • Location: United States

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