Cover story
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Unblocking axonal regeneration
November 5, 2009, Volume 2 / Number 43
Harvard and Case Western scientists have identified a neuronal receptor responsible for impeding axonal regeneration following CNS injury. Next, the researchers plan to create antagonists of the receptor to block its antiregenerative effects.
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Analysis
Norrin vs. VEGF
Teams at Johns Hopkins and Genentech have identified in the retinal neovascularization pathway a trio of potential targets for diseases such as diabetic retinopathy and wet age-related macular degeneration. But further research will first have to determine whether this developmental pathway is also involved in disease and therefore druggable in the adult eye.
Tuning the radio with CD47
NCI researchers think they have found a strategy that not only protects healthy tissue during radiation treatment but also enhances antitumor response, most likely by protecting tumor-infiltrating immune cells.
AD's tangled tail
A new mouse model of Alzheimer's disease suggests that an intracellular domain of amyloid precursor protein—and not β-amyloid—causes the disease. The findings could provide additional mechanistic validation for companies developing molecules that block the production of the intracellular APP domain, including BACE1 and γ-secretase inhibitors.
