Abstract
Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the Retinoic Acid Receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in the vast majority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant fusion proteins that can interfere with X and/or RARα function. Here we will review the relevant conclusions and the open questions that stem from a decade of in vivo analysis of APL pathogenesis in the mouse in transgenic and knock-out models.
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Acknowledgements
This work is supported by the NCI, the De Witt Wallace Fund for Memorial Sloan-Kettering Cancer Center, the Mouse Model of Human Cancer Consortium (MMHCC) and NIH Grants to PP Pandolfi and the Lymphoma & Leukemia Society of which PP Pandolfi is a Scholar. Finally, we are indebted to all the past and present members of the laboratory of Molecular and Developmental Biology (MADB) at the Memorial Sloan-Kettering Cancer Center, working on APL and related subjects.
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Piazza, F., Gurrieri, C. & Pandolfi, P. The theory of APL. Oncogene 20, 7216–7222 (2001). https://doi.org/10.1038/sj.onc.1204855
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DOI: https://doi.org/10.1038/sj.onc.1204855
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