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  • Review Article
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Review Article

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

Oncogene volume 20, pages 1540–1546 (2001)Cite this article

Abstract

Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (Gi, Gq and G12/13) to mediate a great variety of responses, ranging from rapid morphological changes to long-term stimulation of cell proliferation. LPA serves as the prototypic GPCR agonist that activates the small GTPases Ras (via Gi) and RhoA (via G12/13), leading to activation of the mitogen-activated protein kinase (MAPK) cascade and reorganization of the actin cytoskeleton, respectively. This review focuses on our current insights into how Ras-MAPK signaling is regulated by GPCR agonists in general, and by LPA in particular.

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Acknowledgements

Research related to this review is supported by the Dutch Cancer Society, the Centre for Biomedical Genetics and the Netherlands Organization for Scientific Research.

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  1. Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

    Onno Kranenburg & Wouter H Moolenaar

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Kranenburg, O., Moolenaar, W. Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 20, 1540–1546 (2001). https://doi.org/10.1038/sj.onc.1204187

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