Volume 8 Issue 9, September 2001
Crystal structure of ZαDLM (ribbon diagram) in complex with left-handed Z-DNA (yellow stick model). ZαDLM is a Z-DNA binding domain from a tumor-associated protein, DLM-1. This is the second structure reported for a Z-DNA–protein complex. DNA recognition is mediated by direct and water-mediated contacts (protein residues, light blue stick model; water molecules, purple spheres). The recognition mode is similar to that observed in the first Z-DNA–protein structure, suggesting that this family of proteins shares a common Z-DNA binding motif. See pages 761–765.
Editorial
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