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Examination of recent protein structures in the light of present views on the mechanism of protein folding provides clues as to events that may occur during the folding process.
Proteins that interact with RNA are now yielding to high-resolution structural analysis and these studies are going hand-in-hand with dissection of the RNA processing machinery of the spliceosome.
Structural analysis reveals mechanisms of drug resistance to HIV-1 protease inhibitors. These results have implications for the design of drugs and therapeutic strategies to combat drug resistance in AIDS.
Comparison of the position of the haem-ligating methionine in different class I cytochromes c raises issues about the use of this methionine in sequence alignment in this family of proteins.
