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Volume 14 Issue 9, September 2007

Fluorescent labeling techniques have allowed observation of RNA Polymerase II transcription in vivo and in real time. The cover shows such a labeled cell with the transcribing locus highlighted in yellow. Cover by Robert Singer and colleagues.pp 796-806, News and Views p 788

Editorial

  • A committee assembled by the US National Academies has examined why women scientists and engineers are underrepresented in leadership positions in academic institutions and scientific and professional societies. If the committee's recommendations are implemented, it should improve the working environment for both women and men.

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News & Views

  • Using a previously developed method, Singer and co-workers have now labeled RNA transcripts and quantitatively measured the synthesis of RNA in living cells. They find that only a small fraction of the RNA polymerases that bind the promoter actually produce messenger RNA. They also observed much faster elongation than previously reported, along with frequent long pauses.

    • Angus I Lamond
    • Jason R Swedlow
    News & Views
  • A recent study using electron microscopy provides a detailed view of the oligomerization of a protein complex on the surface of a microtubule polymer. The findings point to a new type of interaction that may be well suited to couple the movement of cargo to dynamic cytoskeletal polymers.

    • Sharsti Sandall
    • Arshad Desai
    News & Views
  • Neurotransmitter:sodium symporters, which use sodium gradients for the coupled uptake of sodium and neurotransmitters during synaptic transmission, often display a chloride dependence. New data from two separate groups identify the chloride-binding site for this family of symporters and suggest that the chloride charge facilitates sodium binding and substrate transport.

    • Susan G Amara
    News & Views
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