Enzymes that alter nucleosome structure or position are at the very center of gene and genome regulation, and understanding how, and to what extent, these diverse activities collaborate and control each other to shape the genome for dynamic regulation is a major challenge. A new study provides an important step in this direction by illustrating the cooperative nature of ATP-dependent chromatin-remodeling systems in mammalian cells.
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Varga-Weisz, P. Chromatin remodeling: a collaborative effort. Nat Struct Mol Biol 21, 14–16 (2014). https://doi.org/10.1038/nsmb.2748
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DOI: https://doi.org/10.1038/nsmb.2748