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Taking control of G-quadruplexes

Nature Structural & Molecular Biology volume 12, pages 832–833 (2005)Cite this article

Telomeres are crucial for maintaining the integrity of the genome. Several alternative structures have been proposed for these caps, and understanding their biological significance is a matter of great interest. Probing of native telomeres now reveals that telomere end-binding proteins may control the formation of G-quadruplex DNA in vivo.

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Figure 1: Structures formed by G-rich DNA.
Figure 2: Schematic showing a model mechanism wherein TEBPα-β tethers telomeres to the nuclear matrix and stabilizes G-quadruplex DNA.

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Authors and Affiliations

  1. Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, 64110, Missouri, USA

    Peter Baumann

  2. Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, 66160, Kansas, USA

    Peter Baumann

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  1. Peter Baumann
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Baumann, P. Taking control of G-quadruplexes. Nat Struct Mol Biol 12, 832–833 (2005). https://doi.org/10.1038/nsmb1005-832

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