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In this Viewpoint, Gallagher and Bajorin advance the case for using neoadjuvant chemotherapy in muscle-invasive bladder cancer. They contend that preoperative chemotherapy in these patients would be likely to result in survival benefits similar to those seen in breast and colon cancers.
Despite substantial improvement in the survival data for patients with prostate cancer, almost half of men with localized disease are not cured by surgery or radiation. In this Review Mazhar and Waxman assess the potential of using chemotherapy early in the natural history of prostate cancer.
Many patients with interstitial cystitis (IC) note that particular foods can exacerbate their symptoms. In this Review, Klumpp and Rudick propose a model, based on pelvic-organ crosstalk, for this association between pain symptoms from IC and dietary modification.
Radical cystectomy remains the gold standard for muscle-invasive bladder cancer; however, there is still debate over the best approach for managing advanced bladder cancer. In this Review, Ghoneim and Abol-Enein critically assess the current treatment options for the disorder.
This Case Study by Bedke and colleagues describes a 36-year-old woman who presented to a urology department with a pelvic mass of unknown etiology. The authors highlight the difficulties of diagnosing and treating an inflammatory myofibroblastic tumor of the bladder, which can easily be misdiagnosed as a malignant lesion or sarcoma. In this patient, the authors initially opted for bladder-sparing surgery with planned complete cystectomy if indicated by the final pathologic report.
This article describes the case of a 51-year-old woman with acute renal failure. Bylund and Pais detail the investigations that the patient underwent, the discovery of bilateral, multifocal malacoplakia lesions of the bladder and ureters, and the patient's management with medical therapy and surgery. This case emphasizes that upper urinary tract malacoplakia can present as an aggressive disease, but that renal preservation can be achieved.
