Volume 16 Issue 9, September 2019

A new ecological analysis has shown that antimicrobial consumption is positively associated with decreased antimicrobial susceptibility in Neisseria gonorrhoeae across European countries. Efforts at the policy, provider and community level need to be strengthened to address and help mitigate the continued emergence of antimicrobial resistance in N. gonorrhoeae.

Increasing evidence suggests that patients undergoing trimodality bladder-preserving treatment (TMT) and radical cystectomy have comparable outcomes but many continue to be offered surgery. This Review discusses the development of TMT and highlights how technological and biological advances could inform personalized treatment strategies.

The risk of pelvic nodal involvement in patients with high-risk prostate cancer has led to the development of whole-pelvis radiotherapy (WPRT); however, this approach remains controversial. In this Review, the authors discuss the mixed data surrounding WPRT and consider how advanced imaging techniques and ‘big data’ mining could improve patient selection and optimize WPRT by improving localization of subclinical disease.

This Review by Ricketts and Linehan comprehensively summarizes the findings of The Cancer Genome Atlas analyses of renal cell carcinoma and their clinical implications. The authors highlight unique and shared features of the tumour histological subtypes, their predictive power and their possible utility as therapeutic targets.

Physical activity has been shown to help erectile dysfunction (ED); however, the use of physical activity to actually treat ED is limited, and explicit guidelines are required. In this Review, Allen describes mechanisms underlying the effect and suggests an exercise treatment programme for ED.