Volume 16 Issue 3, March 2019

Despite initial enthusiasm, poor translation of preclinical studies and high-profile scandals involving stem cell research have hindered the field of regenerative urology in recent years. However, consideration of the potential of regenerative approaches to revolutionize patient care ought to reignite interest and begin a renaissance in regenerative urology research.

A large genomic study of upper tract urothelial carcinoma and bladder tumours reveals differences in mutational frequencies and demonstrates a clonal relationship between paired tumours. In addition to these genomic insights, a combined tumour and germline genetic analysis approach is suggested to improve the identification of patients with Lynch syndrome.

The long-term outcomes of the first prospective, multi-institutional, single-arm study of patients with prostate cancer treated with salvage radical prostatectomy after disease recurrence following radiotherapy have recently been published. Durable oncological control was reported, possibly because most patients had low-risk or intermediate-risk prostate cancer at initial diagnosis and the biochemical progression-free survival interval was long.

In this Viewpoint, actor, author, and broadcaster Stephen Fry describes his prostate cancer journey alongside the same story from his surgeon, Ben Challacombe, enabling us to consider “both sides of the scalpel”.

In this Review, the authors describe technologies for image-guided surgery for managing lymphatic metastases in prostate cancer. Refining these technologies should increase precision in the surgical recognition of positive lymph nodes and reduce the morbidity of pelvic lymph node dissection.

Nonoperative management is the only treatment option for Peyronie’s disease in the acute phase of the disease, when surgery is contraindicated. In this Review, Tsambarlis and Levine discuss the oral and topical therapies that have been shown to be efficacious and provide recommendations for their use.

This Review describes the key insights into urologic chronic pelvic pain syndrome (UCPPS) from the first phase of Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network studies and highlights their implications for understanding the pathophysiological basis and clinical management of UCPPS.