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Prostate cancer

Why is PSA velocity such a sticky concept?

Unequivocal randomized trial data show that PSA velocity does not benefit decision making in localized prostate cancer. A recent paper suggests that the literature is wrong and that PSA velocity does predict aggressive disease; however, the study design is flawed and the key claim seems to be based on a typographical error.

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References

  1. Wolters, T., Roobol, M. J., Bangma, C. H. & Schroder, F. H. Is Prostate-Specific Antigen Velocity selective for clinically significant prostate cancer in screening? European Randomized Study of Screening for Prostate Cancer (Rotterdam). Eur. Urol. 55, 385–392 (2009).

    Article  Google Scholar 

  2. Thompson, I. M. et al. Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial. J. Natl Cancer Inst. 98, 529–534 (2006).

    Article  Google Scholar 

  3. Fall, K. et al. Prostate-specific antigen levels as a predictor of lethal prostate cancer. J. Natl Cancer Inst. 99, 526–532 (2007).

    Article  Google Scholar 

  4. Pinsky, P. F. et al. Prostate-specific antigen velocity and prostate cancer Gleason grade and stage. Cancer 109, 1689–1695 (2007).

    Article  Google Scholar 

  5. Andriole, G. L. et al. The effect of dutasteride on the usefulness of prostate specific antigen for the diagnosis of high grade and clinically relevant prostate cancer in men with a previous negative biopsy: results from the REDUCE study. J. Urol. 185, 126–131 (2011).

    Article  CAS  Google Scholar 

  6. Ross, A. E. et al. Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program. J. Clin. Oncol. 28, 2810–2816 (2010).

    Article  CAS  Google Scholar 

  7. Ulmert, D. et al. Long-term prediction of prostate cancer: prostate-specific antigen (PSA) velocity is predictive but does not improve the predictive accuracy of a single PSA measurement 15 years or more before cancer diagnosis in a large, representative, unscreened population. J. Clin. Oncol. 26, 835–841 (2008).

    Article  Google Scholar 

  8. Vickers, A. J., Savage, C., O'Brien, M. F. & Lilja, H. A systematic review of pretreatment PSA velocity and doubling time as predictors for prostate cancer. J. Clin. Oncol. 27, 398–403 (2009).

    Article  Google Scholar 

  9. Wallner, L. P. et al. Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population. BJU lnt. doi: 10.1111/j.1464-410X.2012.11651.x.

  10. Vickers, A. J. Re: an empirical evaluation of guidelines on prostate-specific antigen velocity in prostate cancer detection. J. Natl Cancer Inst. 103, 1635–1636 (2011).

    Article  Google Scholar 

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Vickers, A. Why is PSA velocity such a sticky concept?. Nat Rev Urol 10, 189–190 (2013). https://doi.org/10.1038/nrurol.2013.47

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