Zileuton, a 5-lipoxygenase inhibitor, can reduce torsion–detorsion testicular injury. Testis torsion was carried out in anaesthetized rats, which were treated with either 3 mg/kg zileuton, vehicle or 10 mg/kg montelukast, a leukotriene antagonist. Histopathological injury was reduced in both treatment groups, though only reached significance in the zileuton-treated cohort.