Zileuton, a 5-lipoxygenase inhibitor, can reduce torsion–detorsion testicular injury. Testis torsion was carried out in anaesthetized rats, which were treated with either 3 mg/kg zileuton, vehicle or 10 mg/kg montelukast, a leukotriene antagonist. Histopathological injury was reduced in both treatment groups, though only reached significance in the zileuton-treated cohort.
ORIGINAL RESEARCH PAPER
Isikdemir, F. et al. Effects of montelukast and zileuton on testicular torsion/detorsion injury in rats. Andrologia doi:10.1111/and.12042
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Zileuton protects against torsion injury. Nat Rev Urol 10, 3 (2013). https://doi.org/10.1038/nrurol.2012.226
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DOI: https://doi.org/10.1038/nrurol.2012.226