In our December issue: articles on osteoarthritis therapies, IgG4-related disease, immune-mediated necrotizing myopathy and antinuclear antibody testing.

In our November issue: articles on fibromyalgia, precision medicine in psoriatic arthritis and sex hormones in autoimmune rheumatic diseases.

In our October issue: articles on fibroblast growth factor signalling in osteoarthritis, the role of antinuclear antibodies in SLE, COVID-19-related microangiopathy and patient-centric clinical trials in rheumatology.

In our September issue: articles on the management of giant cell arteritis and polymyalgia rheumatica, cell death in chronic inflammatory diseases, digital health technologies in rheumatology and the clinical application of DNA methylation markers in autoimmune rheumatic diseases.

In our August issue: articles on the gut–joint axis in spondyloarthritis, osteoarthritis therapy, biomarkers in axial spondyloarthritis and inflammatory processes in COVID-19 and arthritis.

In our July issue: articles on prevention of cardiovascular disease in rheumatoid arthritis, pathophysiology of Kawasaki disease and epidemiology of gout.

In our June issue: articles on PAD enzymes and fibroblast-like synoviocytes in rheumatoid arthritis and on the history and development of IL-6-targeted therapies.

In our May issue: articles on lupus nephritis, epigenetics in osteoarthritis and pharmacomicrobiomics in inflammatory arthritis.

In our April issue: articles on mechanical loading in inflammatory arthritis, Raynaud phenomenon and digital ulcers in systemic sclerosis, new concepts in the classification of innate immune-mediated diseases and emerging views on glucocorticoid therapy in rheumatology.

This Focus examines the cellular and molecular mechanisms underlying the therapeutic and adverse effects of various commonly used non-biologic drugs in rheumatology, as well as future prospects in this field.

In our February issue: articles on asymptomatic hyperuricaemia, T cell immunometabolism in SLE, immunomodulatory mechanisms during pregnancy in RA and next-generation immune monitoring in rheumatic disease research.

In our January issue: articles on myofibroblasts in fibrotic diseases, drug repurposing in patients with rheumatic diseases, and behavioural economics in rheumatology.