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For too long, the definition of ‘remission’ in rheumatoid arthritis has been distorted by the widespread use of an inadequate tool, with consequences for clinical care and for making sense of clinical trial data. Has the time come to move away from DAS28-defined remission?
Cartilage has a limited healing capacity; however, studies into the basic biological characteristics, formation and structural maintenance of the cartilage collagen network are providing explanations for the failure of current therapeutic approaches, urging us to rethink our approach to the regeneration of articular cartilage.
