In a substudy of the Dietary Approaches to Stop Hypertension (DASH) trial involving 103 patients with prehypertension or stage 1 hypertension, serum uric acid (SUA) levels were reduced to a greater extent by the blood-pressure-lowering DASH diet than by a control diet (-0.35 mg/dl; 95% CI -0.65 to -0.05, P = 0.02). The effect size of the DASH diet was greatest and approached that of urate-lowering drug therapy in those with hyperuricaemia (n = 8; -1.3 mg/dl; 95% CI -2.50 to -0.08). The substudy also found that compared with a low level of dietary sodium intake, medium and high sodium intake significantly reduced SUA levels regardless of whether patients consumed the DASH diet or the control diet.
References
Juraschek, S. P. et al. Effects of the Dietary Approaches to Stop Hypertension (DASH) diet and sodium intake on serum uric acid. Arth. Rheumatol. http://dx.doi.org/10.1002/art.39813 (2016)
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Shipman, L. Dietary interventions lower serum uric acid levels. Nat Rev Rheumatol 12, 560 (2016). https://doi.org/10.1038/nrrheum.2016.152
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DOI: https://doi.org/10.1038/nrrheum.2016.152