In a substudy of the Dietary Approaches to Stop Hypertension (DASH) trial involving 103 patients with prehypertension or stage 1 hypertension, serum uric acid (SUA) levels were reduced to a greater extent by the blood-pressure-lowering DASH diet than by a control diet (-0.35 mg/dl; 95% CI -0.65 to -0.05, P = 0.02). The effect size of the DASH diet was greatest and approached that of urate-lowering drug therapy in those with hyperuricaemia (n = 8; -1.3 mg/dl; 95% CI -2.50 to -0.08). The substudy also found that compared with a low level of dietary sodium intake, medium and high sodium intake significantly reduced SUA levels regardless of whether patients consumed the DASH diet or the control diet.