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Early treatment of inflammatory demyelinating disease

Multiple sclerosis and neuromyelitis optica—two inflammatory demyelinating diseases with different pathogenesis and treatment regimens—have overlapping clinical manifestations, which can make diagnosis at initial presentation difficult. Now, a new guideline aims to improve early treatment decisions in patients with these disorders, particularly in the Asia–Pacific region.

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References

  1. Comi, G. et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 357, 1576–1582 (2001).

    Article  CAS  Google Scholar 

  2. Carroll, W. M. et al. A guide to facilitate the early treatment in patients with idiopathic demyelinating disease (multiple sclerosis and neuromyelitis optica). Mult. Scler. http://dx.doi.org/10.1177/1352458512471092.

  3. Fukazawa, T. et al. Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders. J. Neurol. Sci. 225, 71–78 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  4. Sellner, J. et al. EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur. J. Neurol. 17, 1019–1032 (2010).

    Article  CAS  PubMed Central  Google Scholar 

  5. Kim, S. H., Kim, W., Li, X. F., Jung, I. J. & Kim, H. J. Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder? Mult. Scler. 18, 1480–1483 (2012).

    Article  PubMed Central  Google Scholar 

  6. Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F. & Weinshenker, B. G. Revised diagnostic criteria for neuromyelitis optica. Neurology 66, 1485–1489 (2006).

    Article  CAS  PubMed Central  Google Scholar 

  7. Morrow, M. J. & Wingerchuk, D. Neuromyelitis optica. J. Neuroophthalmol. 32, 154–166 (2012).

    Article  PubMed Central  Google Scholar 

  8. Ratchford, J. N. et al. Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies. Neurology 73, 302–308 (2009).

    Article  CAS  PubMed Central  Google Scholar 

  9. Fazio, R. et al. Antiaquaporin 4 antibodies detection by different techniques in neuromyelitis optica patients. Mult. Scler. 15, 1153–1163 (2009).

    Article  CAS  PubMed Central  Google Scholar 

  10. Kim, J. E. et al. Brain abnormalities in neuromyelitis optica. J. Neurol. Sci. 302, 43–48 (2011).

    Article  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank M. Freedman, Ottawa Hospital, ON, Canada, for his invaluable comments.

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Correspondence to Naraporn Prayoonwiwat.

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The authors declare no competing financial interests.

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Prayoonwiwat, N., Siritho, S. Early treatment of inflammatory demyelinating disease. Nat Rev Neurol 9, 246–247 (2013). https://doi.org/10.1038/nrneurol.2013.59

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