Two single-nucleotide polymorphisms in the GAPDH gene have been associated with the risk of Parkinson disease (PD) in China. Liu and co-workers recuited 302 patients with PD and 377 healthy controls, and performed a targeted screen for two polymorphisms that had previously been associated with late-onset Alzheimer disease. Carriers of the rs3741918 allele had a lower risk of sporadic PD than did noncarriers (OR 0.74), whereas the rs1060619 variant was associated with an increased risk (OR 1.41).
References
Liu, L. et al. Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population. PLoS ONE 10, e0135425 (2015)
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GAPDH mutations can increase or decrease the risk of PD. Nat Rev Neurol 11, 486 (2015). https://doi.org/10.1038/nrneurol.2015.154
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DOI: https://doi.org/10.1038/nrneurol.2015.154
