Downregulation of K+ channel genes in the injured dorsal root ganglia is one of the hallmarks of neuropathic pain. In a new mouse study, nerve injury increased activity of histone-lysine N-methyltransferase EHMT2 (G9a), resulting in epigenetic silencing of genes encoding K+ channels and transition from acute to chronic neuropathic pain. The findings indicate that G9a is a potential epigenetic target for prevention and treatment of chronic neuropathic pain.