Network effects that underlie the same manifestations of diverse focal lesions can be identified with a lesion mapping approach that requires no specialized imaging, a new study has shown. Connectome data were used to determine the functional connectivity of lesioned brain regions in patients with peduncular hallucinosis. Overlap in connectivity between patients indicated shared disruption of networks that underpinned their symptoms. The approach identified further network effects in central poststroke pain, auditory hallucinosis and subcortical aphasia.