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Transcriptomic analysis of susceptible and resilient subtypes of retinal ganglion cells following injury reveal resilience-associated genes, which when overexpressed in susceptible types increase survival.
Specific subpopulations of vagal mechanoreceptors that sense intestinal stretch are identified by transcriptomic approaches and are shown to induce satiety.
Two studies show that, compared with microglia in anaesthetized mice, microglia in awake mice show reduced surveillance owing to an increase in noradrenaline signalling.
Dendritic activation and action potentials lead to the expression of distinct heterodimers of the inducible transcription factor NPAS4, which show distinct DNA binding patterns; these patterns were recapitulated on exposure of mice to a novel environment.
Three studies show that synaptic interactions between neurons and glioma cells or cells of breast-cancer-to-brain metastases may promote tumour growth.