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In mice, projections from the prelimbic cortex to the nucleus accumbens encode a combination of social and spatial information and may promote 'social investigation' behaviour by enabling social–spatial learning.
Ca2+-independent but voltage-dependent secretion is mediated by the voltage-gated calcium channel subunit CaV2.2, is enabled by SNARE machinery and results in release of ATP or neuropeptide Y.
A study reports that low-amplitude intracortical microstimulation in the premotor cortex can be used to induce movements in monkeys by learned association.
A reduction in the level of T cell intracellular antigen 1, an RNA-binding protein, was protective for tau-induced neuronal death in a mouse model of tauopathy.
Among isogenicCaenorhabditis elegansnematodes, some individuals show biases in aspects of foraging behaviour that persist over development, and this individual-level variation in behaviour is subject to neuromodulatory regulation.
At hippocampal mossy fibre synapses, depolarization-induced facilitation of vesicle release occurs via a cAMP-dependent increase in coupling between Ca2+ channels and vesicle release machinery.
A method that integrates whole-brain neural activity measurements with cellular-level molecular phenotyping is used to investigate the neuronal populations that modulate a global brain state.
In fear conditioning in mice, neurons in the lateral central amygdala that express protein kinase Cδ convey the unconditioned stimulus to the lateral amygdala to enable the encoding of aversive memory.
Methylation of neuronal genes at CA sequences is modulated by neuronal activity during early postnatal periods and fine tunes gene expression in adult neurons.
