News & Comment

It is not known how mammals sense potentially life-threatening reductions in oxygen in the ambient air, but a novel mechanism has been found in mice that involves a novel subpopulation of olfactory sensory neurons that express the soluble guanylate cyclase GUCY1β2.

Unattended information can lie latent in working memory and then be reactivated by transcranial magnetic stimulation.

Shank3deficiency disrupts TRPV1 signalling, pain processing and the induction of heat hyperalgesia in mice.

Deletion ofDgcr8in 22q11.2 deletion syndrome leads to decreased processing of miR-338-3p, leading to an upregulation of thalamic dopamine D2 receptors and auditory thalamocortical deficits that might be associated with antipsychotic-sensitive auditory hallucinations.

The genetic programmes involved in axonal pruning during development are poorly elucidated but are shown to involve a balance between the anti-apoptotic protein DUSP16 and the pro-degenerative protein PUMA.

A brain–spine interface that uses decoded neural activity from motor cortex delivered to an electrical stimulation system in the spine was used to restore locomotor function in a monkey whose leg was paralyzed by spinal injury.

Transplanted embryonic neurons can functionally replace ablated neurons in the primary visual cortex in adult mice.

Following injection into the brain, different strains of tau aggregates induce different presentations of tau neuropathology in a mouse model of tauopathy.

Reductions in the response of the amygdala to dishonesty predict the escalation of self-serving dishonesty.