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Parkinson disease-associated mutations in the gene encoding vacuolar protein sorting-associated protein 35 increase the turnover of dynamin-like protein 1 in the mitochondrial membrane of neurons, leading to mitochondrial fission and neuronal death.
The behavioural phenotype in a mouse model ofMECP2(methyl-CpG-binding protein 2) duplication syndrome can be rescued in adulthood by normalizing MeCP2 levels.
A study in mice shows that manipulating the activity of the cortical fields associated with sweet and bitter tastes mediates the perception of taste and drives associated behaviours.
By vesicular secretion ofD-serine, astrocytes in the hippocampal neurogenic niche regulate dendritic maturation, spine formation and synapse formation of adult-born hippocampal neurons.
An induced pluripotent stem cell-based model of human bipolar disorder reveals hyperexcitability in hippocampal neurons and mimics clinical responsiveness to lithium.
Dopamine D1 receptor-expressing medium spiny neurons in the medial nucleus accumbens shell that project to the lateral hypothalamus mediate rapid control of feeding behaviour in mice.
Pathological variants of FUS that are associated with amyotrophic lateral sclerosis or frontotemporal dementia can form irreversible gel assemblies that trap and impair the function of ribonucleoproteins and, thereby, disrupt protein synthesis.
