News & Comment

A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.

Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe

In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.

Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.

Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.

Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour.

Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.

Two studies show that the claustrum delivers inhibition to different parts of the cortex — the prefrontal cortex and auditory cortex.

Spontaneous activity in the developing auditory system is maintained by a homeostatic mechanism and is important for cochlear neuron subtype specification.

Progressive hyperpolarization of ventricular zone progenitors regulates their sequential differentiation and migration in mouse primary sensory cortex.

A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival.

Synapse formation and function at hippocampal CA1 synapses are shown to be regulated by three classes of leucine-rich repeat-containing adhesion molecules, which act in a modular manner to regulate spine density and synapse function.

Restoring function of the K⁺/Cl^– co-transporter KCC2 in spinal inhibitory interneurons spared after spinal cord injury helps the recovery of hindlimb function in mice.