News & Comment

Neuronal atrophy early in a mouse model of spinal cerebellar ataxia 1 may represent an adaptive mechanism that restores the density of potassium channels in Purkinje neurons, thus normalizing membrane polarization and firing.

Activity-dependent redistribution of cadherin–catenin complexes between neighbouring dendritic spines drives pruning versus maturation.

Neutrophil infiltration of the brain drives cognitive decline in mouse models of Alzheimer disease and is regulated by the integrin LFA-1.

Presynaptic β-neurexins regulate synaptic strength at excitatory synapses by modulating endocannabinoid signalling.

A new study identifies a population of 'speed cells' in the rat medial entorhinal cortex that is likely to contribute to path integration.

The formation of a heteromer between cannabinoid 1 receptor and 5-hydroxytryptamine (serotonin) receptor 2A in the brain is required for cannabinoid-induced cognitive impairment, but not analgesia, in mice.

In the adult mouse CNS, reelin protects against amyloid-β-induced synaptic and behavioural deficits.

A study shows that α-synuclein can inhibit the formation of amyloid plaques in mice.

Specific ensembles of neurons in the basolateral amygdala representing unconditioned stimuli that mediate innate behaviours are also found to be necessary for the expression learned behaviours.

Lung nociceptors contribute to inflammation in a model of allergic asthma, in part by release of vasoactive intestinal peptide, and silencing these neurons may be a promising strategy for reducing inflammation in this disease.