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Acute inflammatory pain can result in long-lasting central sensitization of spinal nociceptive pathways that is masked by upregulation of endogenous opioid signalling via the μ-opioid receptor.
Immunoglobulin-like receptor PIRB and its human homologue LILRB2 are high-affinity receptors for amyloid-β oligomers, and PIRB–amyloid-β interactions regulate synaptic plasticity.
Brain imaging techniques have recently been able to reveal awareness and even allow rudimentary communication in some patients who have been diagnosed as being in the vegetative state. In this Perspective, Fernández-Espejo and Owen discuss these developments and consider their diagnostic, judicial and ethical implications.
The coordinated action of oxytocin and serotonin systems in the nucleus accumbens encodes social reward, shedding new light on the mechanisms underlying social dysfunction.
Inhibiting the expression of a histone-binding protein that declines with age in the human dentate gyrus in young mice leads to memory deficits that are similar to those of aged wild-type mice.
