Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Long-range GABAergic projections from the entorhinal cortex to CA1 of the hippocampus suppress feedforward inhibition to allow Schaffer collateral inputs to potentiate CA1 pyramidal neuron responses.
In mice, an early ablation of myelinating oligodendrocytes can trigger a secondary, CD4+T cell-associated demyelination 30 weeks later, suggesting a possible mechanism for the onset of demyelinating diseases such as multiple sclerosis.
A new study shows that the transient manipulation of neural activity can sometimes have 'off-target' effects, making it challenging to determine the specific neural circuit that generates a particular behaviour.