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In experimental autoimmune encephalitis (a mouse model of multiple sclerosis), type I interferons stimulate the production of aryl hydrocarbon receptor, which is activated by diet- and microbe-derived molecules and limits CNS inflammation.
Slow gamma oscillations during sharp-wave ripples in hippocampus are reduced in mice expressing human APOE4 and this is associated with age-related deficits in learning and memory.
A miniaturized spinning bioreactor is used to generate cerebral organoids that mimic key aspects of human cortical development and that can be used to investigate the effects of Zika virus infection on neural development.
During periods of energy stress, glycolytic enzymes become localized near synaptic release sites and are crucial for maintaining energy levels, the synaptic vesicle cycle and behaviour inCaenorhabditis elegans.
