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The centrosome is crucial for the microtubule dynamics that underlie the radial migration of developing rodent neurons but is not required for axon growth.
A new study examines thalamic innervation of cortical layer 2/3 pyramidal neurons and models how this thalamic connectivity affects visual responses in these cells.
The ability to be woken from deep sleep by a sound (such as an alarm) is shown to be mediated by a specialized glutamatergic brainstem–mediodorsal thalamic pathway.
Different defensive responses are characterized by transient behavioural and cardiac components, which are constrained by cardiovascular dynamics occurring across the duration of threat exposure.
In both human radiation-induced brain injury and a mouse model of this condition, activated microglia release chemokines that attract cytotoxic T cells from the periphery to the lesion site, and this exacerbates neuronal damage in the area.
The representational geometry of neural population activity in the somatosensory cortex of mice allows for high flexibility needed to perform complex tasks and for generalization to novel tasks at the same time.
Ketamine-induced dissociated states in mice result from the suppression and activation of cortical pyramidal neuron populations that are active and silent during wakefulness, respectively.
Hyperactivity in a subset of lateral septum neurons inhibits social reward processing and drives social avoidance following chronic social defeat in mice.
Deletion of Gabrb3, which encodes the β3 subunit of the GABAA receptor selectively in pyramidal neurons of developing mouse sensory cortex, increased contralateral connectivity, network synchrony and sensitivity to tactile stimuli, suggesting that this receptor is involved in refinement of interhemispheric sensory pathways.
Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.
The increased tissue stiffness that results from the presence of Aβ aggregates activates microglial mechanosensitive PIEZO1 channels and drives Aβ engulfment, reducing plaque burden, synapse loss and spatial memory impairment in mice.
Barosensitive neurons in the medullary nucleus of the solitary tract can decrease wakefulness and increase non-REM sleep in mice through the same circuitry that regulates cardiovascular function.
The modern human variant of the gene transketolase-like 1, but not the Neanderthal variant, promotes the production of basal radial glia during neocortical development.