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Detailed transcriptomic analysis of cells within the cortical layers of the human medium temporal gyrus revealed surprising homology with existing mouse transcriptomic data — but also some important differences.
Two studies demonstrate the power of combining induced pluripotent stem cell technology with CRISPR-mediated gene editing to investigate neurobiological mechanisms.
The 15q11.2 copy number deletion, which is associated with an increased risk of psychiatric disorders, is found in rodents to result in reduced myelin thickness, lower functional connectivity and motor deficits.
In zebrafish, pioneer axons of the dorsal root ganglia require the release of synaptic-like vesicles to enter the spinal cord, suggesting that synaptic vesicles have a role in circuit formation ahead of synaptogenesis.
GABAergic neurons of the dorsal raphe nucleus play a role in energy balance regulation via indirect projections to brown adipose tissue where they regulate thermogenesis.
The encoding of salient events as memory traces involves the selective activation of specific neurons in the hippocampus and the inhibition of others, a process shown here to be regulated by GABAergic input from the nucleus incertus in the brainstem.