Abstract

The input–output relationship of neuronal networks depends both on their synaptic connectivity and on the intrinsic properties of their neuronal elements. In addition to altered synaptic properties, profound changes in intrinsic neuronal properties are observed in many CNS disorders. These changes reflect alterations in the functional properties of dendritic and somatic voltage- and Ca²⁺-gated ion channels. The molecular mechanisms underlying this intrinsic plasticity comprise the highly specific transcriptional or post-transcriptional regulation of ion-channel expression, trafficking and function. The studies reviewed here show that intrinsic plasticity, in conjunction with synaptic plasticity, can fundamentally alter the input–output properties of neuronal networks in CNS disorders.

Author affiliations

1. Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
2. Department of Physiology, Institute of Medical Sciences, Hebrew University-Hadassah Faculty of Medicine, 91120 Jerusalem, Israel.

Correspondence to: Heinz Beck¹ Email: heinz.beck@ukb.uni-bonn.de

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