How individual CA1 pyramidal cells (PCs) contribute to spatial memory is not well understood. Changes in intracellular Ca2+ levels in specific PCs (indicating their place field) in superficial and deep layers of CA1 in mice were measured during a spatial-navigation task and a goal-oriented learning task. Superficial-PC place maps were more stable than deep-PC maps during the exploration task, but deep-PC place maps were more stable during the goal-oriented learning task, indicating functional specialization of PCs along the radial axis of CA1.
References
Danielson, N. B. et al. Sublayer-specific coding dynamics during spatial navigation and learning in hippocampal area CA1. Neuron http://dx.doi.org/10.1016/j.neuron.2016.06.020 (2016)
Rights and permissions
About this article
Cite this article
Lewis, S. Location, location, location. Nat Rev Neurosci 17, 535 (2016). https://doi.org/10.1038/nrn.2016.106
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrn.2016.106
