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Corticotropin-releasing factor (CRF) and urocortins have traditionally been proposed to promote stress and stress recovery, respectively. However, recent findings suggest that this view is overly simplistic. Chen and colleagues review evidence showing that CRF-receptor signalling is region- and cell type-specific and influenced by the individual's experience.
The connectivity pattern of the left occipitotemporal cortex of 5-year-olds who cannot yet read can predict where the functionally specific 'visual word form area' will form once the children learn to read.
NMDA receptors that contain GluN3 subunits have several non-conventional properties that set them apart from 'classical' NMDA receptors. Pérez-Otaño and colleagues describe the important roles of these receptors in CNS development and their potential involvement in CNS disease.
InDrosophila melanogaster, signals of water satiety and hunger converge on interoceptive neurons in the suboesophageal zone that in turn influence water intake and feeding.
Using data from the Human Connectome Project and a semi-automated neuroanatomical approach, a study has generated a new multi-modal parcellation of the human cerebral cortex.
Axons and dendrites contain distinct complements of membrane proteins, consistent with their different roles in electrochemical signalling. In this Review, Bentley and Banker discuss the intracellular machinery that ensures that axonal and dendritic proteins are accurately targeted to the correct domains.