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In recent years the function of NG2-expressing cells in the developing and adult CNS has attracted the attention of many researchers. Nishiyama and colleagues discuss recent findings and the outstanding questions about these cells' lineage and contribution to CNS function.
Activated glia exert both positive and negative effects on pain processing. Milligan and Watkins review the molecular mechanisms that underlie neuron–glia interactions in this context. Manipulation of these interactions could represent a new and more efficient approach to treating chronic pain.
The anterior insular cortex is activated by a wide range of conditions and behaviours that go beyond interoception. In a provocative Perspective, Bud Craig proposes that the anterior insula has a fundamental role in human awareness.
