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This study found a new role for chaperone–usher pathway (CUP) pili in the colonization of the gut by uropathogenicEscherichia coli(UPEC) and identified a mannoside compound that could be used to prevent their binding to host cells.
This study presents cryo-electron microscopy structures of the type I-E Cascade and provides insights into PAM-dependent R-loop formation, Cas3 recruitment and substrate handover.
In this study, Patel, Whiteet al. discover that the hepatitis B virus pre-genome RNA contains specific nucleotide motifs that mediate interactions with the viral capsid protein to drive nucleocapsid assembly.
This month's Genome Watch highlights how sequencing the genomes of multiple bacterial isolates from humans and animal infection models has revealed the presence of mutations that might represent adaptations for persistence in the host.
Many bacteria can infect and persist inside their hosts for long periods of time. In this Review, Fisher, Gollan and Helaine discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections.
The microbiota influences the development of cancer and the effect of cancer therapies. In this Review, the authors summarize the interactions between the microbiota, the immune system and tumours and how manipulation of the microbiota can be used therapeutically.
Plasmodium falciparumexports several variant antigens to the surface of erythrocytes. In this Review, Wahlgren, Goel and Akhouri discuss the three best characterized of these protein families, PfEMP1, RIFIN and STEVOR, and highlight their role in the development of severe malaria.
Archaea are highly diverse microorganisms that inhabit various environments. This evolutionary flexibility and adaptability has been supported by abundant horizontal gene transfer. In this Review, Albers and colleagues discuss the mechanisms and consequences of archaeal DNA transfer.
Zoonotic diseases present a substantial global health burden. In this Opinion article, Plowrightet al. present an integrative conceptual and quantitative model that reveals that all zoonotic pathogens must overcome a hierarchical series of barriers to cause spillover infections in humans.
