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Two recent studies report the development of monoclonal antibodies directed against novel epitopes within the viral envelope protein of dengue virus that prevent severe infection in mouse models.
A new study shows that aBacillus subtilisbiofilm community uses metabolic co-dependency to produce growth oscillations that resolve a siege-like metabolic conflict.
This study uses a new tool, VirSorter, to search for virus genomes within all publicly available bacterial and archaeal genomic datasets and finds 264 new candidate viral genera.
This month's Genome Watch explores recent findings on the global population structure and the origin of the successfulMycobacterium tuberculosisBeijing lineage revealed by high-throughput sequencing of global bacterial collections.
During recurrent staphylococcal infections,Staphylococcus aureususes several strategies to evade detection by the host immune system. In this Review, Schneewind and colleagues describe the staphylococcal factors that manipulate innate and adaptive immune responses through inhibition, modification and phagocyte destruction.
In this Review, Lemon and colleagues describe the interactions of the RNA genome of hepatitis C virus with various host proteins and microRNAs. They discuss how these interactions affect viral RNA synthesis and decay, and how they influence the long-term persistence of the virus.
In this Review, Sourjik and Typas describe the principles of protein–protein interaction networks and the current experimental approaches used to probe these networks in bacteria. They consider how these techniques have led to an increased understanding of the chemotaxis and cell cycle networks inEscherichia coli, highlighting the applicability of such methods to understanding diverse bacterial processes.
For transmission from mammalian host to mosquito vector, blood-stage malaria parasites must convert from an asexual form to the sexual gametocyte through a process known as gametocytogenesis. In this Review, Josling and Llinás discuss recent studies that have begun to elucidate the molecular basis of this process, in particular the factors involved in commitment to gametocytogenesis.
Following host cell invasion, many bacterial and parasitic pathogens hide from the immune system in an intracellular vacuolar niche. In this Opinion article, Mota and colleagues discuss how these 'professional' vacuolar pathogens can remain susceptible to recognition and clearance by the host.
