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Environmental microbiology

Exploring diversity with single-cell genomics

Nature Reviews Microbiology volume 11, pages 598–599 (2013)Cite this article

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large-scale studies have used single-cell genomics to recover bacterial and archaeal genomes

Metagenomic studies have greatly enhanced our understanding of bacterial and archaeal diversity. However, environmental metagenomic data often do not allow the genomes of individual species to be assembled, and therefore most complete genome sequences have been obtained from cultured microorganisms. Now, two new large-scale studies have used single-cell genomics to recover bacterial and archaeal genomes directly from uncultured environmental samples.

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References

  1. Rinke, C. et al. Insights in the phylogeny and coding potential of microbial dark matter. Nature http://dx.doi.org/10.1038/nature12352 (2013)

  2. Swan, B. K. et al. Prevalent genome streamlining and latitudinal divergence of planktonic bacteria in the surface ocean. Proc. Natl Acad. Sci. USA 110, 11463–11468 (2013)

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  1. Ursula Hofer
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Lasken, R. S. Genomic sequencing of uncultured microorganisms from single cells. Nature Rev. Microbiol 10, 631–640 (2012)

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Hofer, U. Exploring diversity with single-cell genomics. Nat Rev Microbiol 11, 598–599 (2013). https://doi.org/10.1038/nrmicro3095

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