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This Progress article looks at recent developments in our understanding of the role of the host factor Alix in both retroviral and cellular membrane budding and fission events.
In addition to their phagocytic activity, neutrophils can also kill microorganisms by the release of neutrophil extracellular traps or NETs — fibrous extracellular structures that are composed of chromatin with proteins from the neutrophilic granules attached. Brinkmann and Zychlinsky provide an overview of the structure, function and generation of NETs.
Pathogenic microorganisms have evolved numerous mechanisms that enable their exploitation of host cell function. This Progress article explores recent evidence suggesting how one group of diverse bacterial pathogens use a common strategy to manipulate the expression of the Kruppel-like factor (KLF) family of mammalian transcriptional regulators.
