News & Comment

RIP1–RIP3 complexes form amyloid-like fibrils to promote programmed necrosis.

MMS19-mediated Fe–S protein biogenesis is crucial for DNA metabolism.

Silencing established by both endogenous piRNAs and environmental RNAi can be transmitted through generations.

α-catenin and centralspindlin control RHO signalling at adherens junctions.

p53 triggers necrosis by inducing the opening of mitochondrial permeability transition pore (PTP).

HP1Swi6 binding with heterochromatic mRNAs triggers its dissociation from chromatin to promote mRNA decay.

BUBR1 is a pseudokinase and uses its kinase domain for structural integrity.

SCUBE2 facilitates the release of lipid-modified sonic hedgehog from the plasma membrane.

β-catenin regulates the expression of the telomerase catalytic subunit TERT.

This study identifies Atg36 as the selective receptor for pexophagy.

NEMO acts as a scaffold directing IKKβ activity to IκB.

PABP enhances translation repression by facilitating miRISC association with target mRNAs.

mTORC1 inhibition in Paneth cells promotes ISC self-renewal following calorie restriction.

Nuclear ribonucleoproteins can be exported by budding of the nuclear envelope.

O-GlcNAcylation of OCT4 regulates pluripotency.

Reversible, domain-driven RNA-binding protein (RBP) polymerization underlies RNA granule formation.

Cells can switch between lamellipodium-based and lobopodium-based migration in 3D.

ZNRF3 lowers WNT receptor membrane levels and R-spondin controls this inhibitory function.

Prions block the cell cycle by sequestering a spindle body component.

ER-mediated sorting of peroxisomal translocon components controls peroxisome biogenesis.