Cellular microbiology: Virus plays dead | PDF (211 KB)

p422 | doi:10.1038/nrm2420

DNA repair: Working on different ends | PDF (154 KB)

p423 | doi:10.1038/nrm2411

Cell signalling: Dynamic redistribution | PDF (189 KB)

p423 | doi:10.1038/nrm2413

DNA replication: Follow the path | PDF (289 KB)

p424 | doi:10.1038/nrm2409

Cell signalling: A Rac1–JNK2–-catenin domino cascade | PDF (172 KB)

p424 | doi:10.1038/nrm2412

Cell migration: The importance of being selective | PDF (232 KB)

p426 | doi:10.1038/nrm2422

Small RNAs: Endo-siRNAs truly endogenous | PDF (137 KB)

p426 | doi:10.1038/nrm2424

Gene expression: Pioneering research | PDF (238 KB)

p427 | doi:10.1038/nrm2416

Membrane nanotubes: dynamic long-distance connections between animal cells

Daniel M. Davis & Stefanie Sowinski

p431 | doi:10.1038/nrm2399

Membrane nanotubes are thin extensions of the plasma membrane that connect cells transiently and might facilitate intercellular communication. Recent studies have revealed considerable heterogeneity in their structure, formation, mode of cargo transport and functional properties, depending on the cell types involved.

• Abstract
• Full Text
• PDF (689 KB)

Multiple roles for lipids in the Hedgehog signalling pathway

Suzanne Eaton

p437 | doi:10.1038/nrm2414

Sterols and sterol derivatives modulate the Hedgehog (Hh) pathway at multiple levels. Progress in understanding Hh signalling will depend on deepening our knowledge of the cell biology of sterol metabolism and trafficking.

• Abstract
• Full Text
• PDF (534 KB)

Filopodia: molecular architecture and cellular functions

Pieta K. Mattila & Pekka Lappalainen

p446 | doi:10.1038/nrm2406

Filopodia are thin, actin-rich, finger-like structures that are involved in numerous cellular processes, such as cell migration, wound healing, neurite outgrowth and embryonic development. But what are the mechanisms that regulate filopodia formation in distinct cell types?

• Abstract
• Full Text
• PDF (802 KB)

Changing directions in the study of chemotaxis

Robert R. Kay, Paul Langridge, David Traynor & Oliver Hoeller

p455 | doi:10.1038/nrm2419

Chemotaxis enables immune cells to reach sites of infection, wounds to heal and the formation of embryonic patterns. Recent results have shed light on how cells orientate in chemotactic gradients, the forces that enable pseudopodia projection and the role of the endocytic cycle in movement.

• Abstract
• Full Text
• PDF (813 KB)
• Supplementary information

See also: Correspondence by Hallett et al. | Author Reply by Kay et al.

Spatial and temporal coordination of mitosis by Ran GTPase

Paul R. Clarke & Chuanmao Zhang

p464 | doi:10.1038/nrm2410

The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis and directs nuclear-envelope dynamics, assembly of the mitotic spindle and the timing of cell-cycle transitions.

• Abstract
• Full Text
• PDF (1,002 KB)

The septin family of GTPases: architecture and dynamics

Christine S. Weirich, Jan P. Erzberger & Yves Barral

p478 | doi:10.1038/nrm2407

How do septins, GTP-binding proteins, function in a wide range of cellular processes, such as cell division, cytoskeletal organization and membrane remodelling? Electron microscopy and crystallographic studies provide a glimpse into septin-complex assembly that could answer this question.

• Abstract
• Full Text
• PDF (1,677 KB)
• Supplementary information