Analysis
Nature Reviews Molecular Cell Biology 9, 402-412 (May 2008) | doi:10.1038/nrm2395
Transcriptional control of human p53-regulated genes
Todd Riley1,2, Eduardo Sontag2,3, Patricia Chen1 & Arnold Levine1,4 About the authors
Abstract
The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
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Author affiliations
- The Institute for Advanced Study, Princeton, New Jersey, USA.
- The BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, USA.
- The Mathematics Department, Rutgers University, Piscataway, New Jersey, USA.
- The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Correspondence to: Todd Riley1,2 Email: triley@ias.edu
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