Analysis
Nature Reviews Molecular Cell Biology 9, 402-412 (May 2008) | doi:10.1038/nrm2395
Transcriptional control of human p53-regulated genes
Todd Riley1,2, Eduardo Sontag2,3, Patricia Chen1 & Arnold Levine1,4 About the authors
Abstract
The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
- View At a Glance
Author affiliations
- The Institute for Advanced Study, Princeton, New Jersey, USA.
- The BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, USA.
- The Mathematics Department, Rutgers University, Piscataway, New Jersey, USA.
- The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Correspondence to: Todd Riley1,2 Email: triley@ias.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Essential role of Id2 in negative regulation of IgE class switchingNature Immunology Article (01 Jan 2003)
High-throughput SELEX?SAGE method for quantitative modeling of transcription-factor binding sitesNature Biotechnology Research (01 Aug 2002)
