Membrane trafficking: Efficient recycling | PDF (133 KB)

p90 | doi:10.1038/nrm2345

Lipids: Cofilin set free | PDF (134 KB)

p91 | doi:10.1038/nrm2340

Nuclear transport: Exit for fly mRNA | PDF (454 KB)

p92 | doi:10.1038/nrm2333

Small RNAs: Multi-tasking Argonautes | PDF (132 KB)

p92 | doi:10.1038/nrm2339

Cell polarity: Heads or tails? | PDF (132 KB)

p94 | doi:10.1038/nrm2337

Lipids: Orientating with PtdIns(3,4,5)P₃ | PDF (155 KB)

p94 | doi:10.1038/nrm2341

Chromosome segregation: Tension rules | PDF (163 KB)

p95 | doi:10.1038/nrm2331

Membrane recognition by phospholipid-binding domains

Mark A. Lemmon

p99 | doi:10.1038/nrm2328

Numerous protein domains bind to membrane phospholipids and drive the relocalization of proteins that are involved in crucial cell-signalling and membrane-trafficking events. Precise control of the timing and location of membrane association involves several mechanisms.

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Membrane lipids: where they are and how they behave

Gerrit van Meer, Dennis R. Voelker & Gerald W. Feigenson

p112 | doi:10.1038/nrm2330

A detailed model of the composition and structure of membranes exists. But how do cells orchestrate numerous enzymes, as well as the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?

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Cellular cholesterol trafficking and compartmentalization

Elina Ikonen

p125 | doi:10.1038/nrm2336

Cholesterol is an essential structural component in the cell membranes of most vertebrates. Increased understanding of the metabolism and functional compartmentalization of cholesterol and how this is related to the organ systems level should provide insights into the physiology of cholesterol trafficking.

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Principles of bioactive lipid signalling: lessons from sphingolipids

Yusuf A. Hannun & Lina M. Obeid

p139 | doi:10.1038/nrm2329

The sphingolipids constitute an important class of bioactive lipids that includes ceramide and sphingosine-1-phosphate (S1P). Deciphering the cellular functions of sphingolipids requires an understanding of the complex metabolic pathways and the mechanisms that regulate lipid generation and lipid action.

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Inositol derivatives: evolution and functions

Robert H. Michell

p151 | doi:10.1038/nrm2334

Inositols and their derivatives are versatile molecules that have varied functions and distributions across the three kingdoms of life. How is it that inositol derivatives became ubiquitous and diverse in eukaryotes, and how might the various functions of these molecules have emerged during eukaryote diversification?

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Lipid signalling in disease

Matthias P. Wymann & Roger Schneiter

p162 | doi:10.1038/nrm2335

Lipids function as extracellular and intracellular messengers in a complex lipid signalling network that controls important cellular processes. Imbalances in this network contribute to the pathogenesis of different diseases, including cancer, inflammation and metabolic syndrome, which therefore share common points of therapeutic intervention.

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