Table of contents
September 2006 Vol 7 No 9
From the editors
p623 | doi:10.1038/nrm2014
Research Highlights
Ageing: Connected clues?
p624 | doi:10.1038/nrm2015
Mechanisms of disease: Receptor traffic — parkin rules
p625 | doi:10.1038/nrm2010
In brief
Apoptosis | DNA repair | Molecular motors | Cytokinesis
p625 | doi:10.1038/nrm2018
Development: Controlling size
p626 | doi:10.1038/nrm2004
Protein folding: Avoiding overload
p626 | doi:10.1038/nrm2006
Webwatch
Cell signalling condensed
p626 | doi:10.1038/nrm2012
Structure Watch
Start as you mean to go on | A dimer of dimers
p627 | doi:10.1038/nrm2013
Signal transduction: Up close and personal
p628 | doi:10.1038/nrm2017
Tumorigenesis: Decidedly different
p628 | doi:10.1038/nrm2019
Apoptosis: Model behaviour
p629 | doi:10.1038/nrm2016
Endocytosis: Enter to silence
p630 | doi:10.1038/nrm2007
Cytoskeleton: Nibbling away at actin organization
p630 | doi:10.1038/nrm2011
Reviews
SNAREs — engines for membrane fusion
Reinhard Jahn & Richard H. Scheller
p631 | doi:10.1038/nrm2002
Since their discovery in the late 1980s, SNARE proteins have been recognized as key components of protein complexes that drive intracellular membrane fusion. Despite considerable sequence divergence, their mechanism seems to be conserved and is adaptable for diverse fusion reactions.
The anaphase promoting complex/cyclosome: a machine designed to destroy
Jan-Michael Peters
p644 | doi:10.1038/nrm1988
The anaphase promoting complex/cyclosome (APC/C) is the largest known complex that catalyses ubiquitylation reactions and has key functions in the eukaryotic cell cycle. Recent studies have shed light on how APC/C activity is controlled and how it recognizes a multitude of substrates.
Genome-wide patterns of histone modifications in yeast
Catherine B. Millar & Michael Grunstein
p657 | doi:10.1038/nrm1986
The recent mapping of histone modifications across the Saccharomyces cerevisiae genome has allowed the analysis of how combinations of modified and unmodified chromatin states relate to each other and particularly to chromosomal landmarks, such as heterochromatin, centromeres, promoters and coding regions.
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Jesús Gil & Gordon Peters
p667 | doi:10.1038/nrm1987
The INK4b–ARF–INK4a locus encodes three proteins that are implicated in senescence and tumour suppression. Individual genes are controlled by positive and negative regulators in different contexts, and the entire locus might be suppressed by a cis-acting regulatory domain or by Polycomb-group repressors.
Notch signalling: a simple pathway becomes complex
Sarah J. Bray
p678 | doi:10.1038/nrm2009
The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation.
Perspectives
Innovation
High-throughput fluorescence microscopy for systems biology
Rainer Pepperkok & Jan Ellenberg
p690 | doi:10.1038/nrm1979
Fluorescence microscopy is a powerful tool to assay biological processes in intact living cells. Now, fluorescence microscopy is becoming a quantitative and high-throughput technology that can be applied to functional genomics experiments and can provide data for systems-biology approaches.
Opinion
Metabolic cycles as an underlying basis of biological oscillations
Benjamin P. Tu & Steven L. McKnight
p696 | doi:10.1038/nrm1980
What is the driving force behind periodic biological oscillations such as the circadian, hibernation and sleep–wake cycles? Temporal compartmentalization of metabolism has been shown in budding yeast, and might form the underlying basis for many of the rhythmic phenomena in biology.
