Review

Nature Reviews Molecular Cell Biology 7, 644-656 (September 2006) | doi:10.1038/nrm1988

The anaphase promoting complex/cyclosome: a machine designed to destroy

Jan-Michael Peters1  About the author

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The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

Author affiliations

  1. Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
    Email: peters@imp.univie.ac.at

Published online 9 August 2006

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