Review
Nature Reviews Molecular Cell Biology 7, 589-600 (August 2006) | doi:10.1038/nrm1983
Article series: Mechanisms of disease
Regulation of cardiac hypertrophy by intracellular signalling pathways
Joerg Heineke1 & Jeffery D. Molkentin1 About the authors
Abstract
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.
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Author affiliations
- Department of Pediatrics, University of Cincinnati, Children's Hospital Medical Center, Division of Molecular Cardiovascular Biology, 3333 Burnet Ave, Cincinnati, Ohio 45229.
Correspondence to: Jeffery D. Molkentin1 Email: jeff.molkentin@cchmc.org
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