Review
Nature Reviews Molecular Cell Biology 7, 505-516 (July 2006) | doi:10.1038/nrm1962
EGF–ERBB signalling: towards the systems level
Ami Citri1 & Yosef Yarden1 About the authors
Abstract
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
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Author affiliations
- Department of Biological Regulation, the Weizmann Institute of Science, 1 Hertzl Street, Rehovot 76100, Israel.
Correspondence to: Yosef Yarden1 Email: yosef.yarden@weizmann.ac.il
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